TY - JOUR T1 - Rectus Sheath Block (RSB) Analgesia Could Enhance Significantly the Patient Satisfaction Following Midline Laparotomy in Benign Disease and in Cancer: A Prospective Study With Special Reference to Nitrosative Stress Marker Nitrotyrosine (NT) Plasma Concentrations JF - Anticancer Research JO - Anticancer Res SP - 1383 LP - 1389 DO - 10.21873/anticanres.13252 VL - 39 IS - 3 AU - VIIVI KUOSMANEN AU - IINA SAIMANEN AU - DINA RAHKOLA AU - JARI KÄRKKÄINEN AU - TUOMAS SELANDER AU - MARTIN PURDY AU - HANNU KOKKI AU - MERJA KOKKI AU - MATTI ESKELINEN Y1 - 2019/03/01 UR - http://ar.iiarjournals.org/content/39/3/1383.abstract N2 - Background/Aim: Our hypothesis was that rectus sheath block (RSB) analgesia could enhance satisfaction following midline laparotomy in patients with benign disease and cancer patients. Patients and Methods: Initially, 56 patients were randomized into four groups; control group (n=12), single-dose (n=16), repeated-dose (n=12) and continuous infusion (n=16) RSB analgesia groups. The plasma concentrations of the NT marker were measured just before, immediately after and 24 h after operation. Patient satisfaction at 24 h postoperatively was filed on a 11-point numeric rating scale (SFS24; 0=fully unsatisfied; 10=fully satisfied). Results: The RSB analgesia significantly enhanced the SFS24 scores in the study groups (p=0.001). The median plasma NT concentrations (pg/ml) following surgery (POP1) were significantly lower in patients with cancer versus patients with benign disease (5.3 vs. 7.6, p=0.008). Jitter plots of the individual SFS24 values versus plasma NT concentrations were significantly correlated in benign and cancer patients (r=−0.284, p=0.028). Conclusion: The RSB analgesia could significantly enhance patient satisfaction following midline laparotomy. Plasma NT concentrations versus patient satisfaction following surgery are significantly correlated in benign disease and cancer. ER -