RT Journal Article SR Electronic T1 An MGMT Allelic Variant Can Affect Biochemical Relapse in Prostate Cancer Patients JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 369 OP 379 DO 10.21873/anticanres.16172 VO 43 IS 1 A1 FURINI, HECTOR HUGO A1 FUKUSHIMA, KEVIN SANTIAGO DE SOUZA QUENZO A1 DE NÓBREGA, MONYSE A1 DE SOUZA, MARILESIA FERREIRA A1 RODRIGUES, MILENE ROLDÃO SOUZA A1 DE MATTOS, BEATRIZ BOCATTE A1 GUEMBAROVSKI, ROBERTA LOSI A1 FUGANTI, PAULO EMÍLIO A1 SIMÃO, ANDREA NAME COLADO A1 FLAUZINO, TAMIRES A1 CÓLUS, ILCE MARA DE SYLLOS YR 2023 UL http://ar.iiarjournals.org/content/43/1/369.abstract AB Background/Aim: Prostate cancer (PCa) is one of the most frequent neoplasms in men around the world. In recent years, the search for new biomarkers with greater prognostic potential for PCa has intensified. This study aimed to evaluate single nucleotide polymorphisms (SNPs) and a combined panel of these polymorphisms in relation to biochemical recurrence in patients who were through prostatectomy, with an average of 7 years of follow-up. Materials and Methods: Patients diagnosed with PCa (n=197) participated in this cohort study. Thirteen SNPs were analyzed: rs2279115 (BCL-2), rs26677604 (CASP3), rs1052571 (CASP9), rs11781886 (NKX3-1), rs2735343 (PTEN), rs2494750 (AKT1), rs2699887 (PI3KCA), rs3195676 (AMACR), rs17302090 (AR), rs2536 (mTOR), rs1695 (GSTP1), rs2308321 (MGMT) and rs1544410 (VDR). Variants were combined and four main panels were defined: cell death, cell survival, growth receptors, and metabolism. Genotyping was performed by real-time PCR. Results: We did not observe any significant relation between the panels of variants analyzed, apart from the rare allele (G) of rs2308321 (MGMT) that was associated with a higher risk of recurrence (p=0.036) when compared to the prevalent (A) in the allelic model. Conclusion: This MGMT variant occurs in an exon, and it could potentially affect DNA repair and, therefore, the biochemical relapse of PCa patients.