PT  - JOURNAL ARTICLE
AU  - FURINI, HECTOR HUGO
AU  - FUKUSHIMA, KEVIN SANTIAGO DE SOUZA QUENZO
AU  - DE NÓBREGA, MONYSE
AU  - DE SOUZA, MARILESIA FERREIRA
AU  - RODRIGUES, MILENE ROLDÃO SOUZA
AU  - DE MATTOS, BEATRIZ BOCATTE
AU  - GUEMBAROVSKI, ROBERTA LOSI
AU  - FUGANTI, PAULO EMÍLIO
AU  - SIMÃO, ANDREA NAME COLADO
AU  - FLAUZINO, TAMIRES
AU  - CÓLUS, ILCE MARA DE SYLLOS
TI  - An <em>MGMT</em> Allelic Variant Can Affect Biochemical Relapse in Prostate Cancer Patients
AID  - 10.21873/anticanres.16172
DP  - 2023 Jan 01
TA  - Anticancer Research
PG  - 369--379
VI  - 43
IP  - 1
4099  - http://ar.iiarjournals.org/content/43/1/369.short
4100  - http://ar.iiarjournals.org/content/43/1/369.full
SO  - Anticancer Res2023 Jan 01; 43
AB  - Background/Aim: Prostate cancer (PCa) is one of the most frequent neoplasms in men around the world. In recent years, the search for new biomarkers with greater prognostic potential for PCa has intensified. This study aimed to evaluate single nucleotide polymorphisms (SNPs) and a combined panel of these polymorphisms in relation to biochemical recurrence in patients who were through prostatectomy, with an average of 7 years of follow-up. Materials and Methods: Patients diagnosed with PCa (n=197) participated in this cohort study. Thirteen SNPs were analyzed: rs2279115 (BCL-2), rs26677604 (CASP3), rs1052571 (CASP9), rs11781886 (NKX3-1), rs2735343 (PTEN), rs2494750 (AKT1), rs2699887 (PI3KCA), rs3195676 (AMACR), rs17302090 (AR), rs2536 (mTOR), rs1695 (GSTP1), rs2308321 (MGMT) and rs1544410 (VDR). Variants were combined and four main panels were defined: cell death, cell survival, growth receptors, and metabolism. Genotyping was performed by real-time PCR. Results: We did not observe any significant relation between the panels of variants analyzed, apart from the rare allele (G) of rs2308321 (MGMT) that was associated with a higher risk of recurrence (p=0.036) when compared to the prevalent (A) in the allelic model. Conclusion: This MGMT variant occurs in an exon, and it could potentially affect DNA repair and, therefore, the biochemical relapse of PCa patients.