PT  - JOURNAL ARTICLE
AU  - CHIN-CHENG SU
AU  - GUANG-WEI CHEN
AU  - JAUNG-GENG LIN
AU  - LII-TZU WU
AU  - JING-GUNG CHUNG
TI  - Curcumin Inhibits Cell Migration of Human Colon Cancer Colo 205 Cells through the Inhibition of Nuclear Factor kappa B /p65 and Down-regulates Cyclooxygenase-2 and Matrix Metalloproteinase-2 Expressions
DP  - 2006 Mar 01
TA  - Anticancer Research
PG  - 1281--1288
VI  - 26
IP  - 2A
4099  - http://ar.iiarjournals.org/content/26/2A/1281.short
4100  - http://ar.iiarjournals.org/content/26/2A/1281.full
SO  - Anticancer Res2006 Mar 01; 26
AB  - Curcumin (diferuloylmethane) is a chemical derived from several Curcuma species (turmeric), possessing anti-inflammatory and antioxidant properties and which, thus, may be a potential anticancer drug. However, its mechanism of action is not fully understood. Our previous studies had shown that curcumin induced cytotoxicity, cell cycle arrest and apoptosis in human colon cancer colo 205 cells. In this study, curcumin affected the levels of NF-κB/ p65 in a time-dependent manner but did not affect NF-κB/ p50, based on Western blotting methods. In vitro experiments revealed that curcumin inhibited Cox-2 levels, but promoted those of Cox-1 in colo 205 cells. Curcumin also inhibited MMP-2 levels and promoted MMP-9 levels, but did not affect MMP-7 levels, based on Western blotting assays. These effects were also confirmed by cDNA microarray. Remarkably, curcumin not only exerted its effect on the protein levels of NF-κB, Cox-1 and -2, MMP-2 and -7, but also directly inhibited their mRNA levels. Curcumin was also found to significantly repress the in vitro invasion of colo 205 cells. Copyright© 2006 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved