PT  - JOURNAL ARTICLE
AU  - YOICHI HAMAI
AU  - MANABU EMI
AU  - YUTA IBUKI
AU  - TOMOAKI KUROKAWA
AU  - TORU YOSHIKAWA
AU  - MANATO OHSAWA
AU  - RYOSUKE HIROHATA
AU  - NAO KITASAKI
AU  - MORIHITO OKADA
TI  - Correlation Between Tumor Uptake on FDG-PET and Malignant Features in Esophageal Squamous Cell Carcinoma After Neoadjuvant Chemotherapy Followed by Surgery
AID  - 10.21873/anticanres.16115
DP  - 2022 Dec 01
TA  - Anticancer Research
PG  - 6037--6045
VI  - 42
IP  - 12
4099  - http://ar.iiarjournals.org/content/42/12/6037.short
4100  - http://ar.iiarjournals.org/content/42/12/6037.full
SO  - Anticancer Res2022 Dec 01; 42
AB  - Background/Aim: To identify the correlations between the 18F-fluorodeoxyglucose (FDG) uptake on positron emission tomography (PET) images and the pathological features and recurrence among patients with esophageal squamous cell carcinoma (ESCC) who were administered neoadjuvant chemotherapy (NAC) followed by surgery. Patients and Methods: We assessed the correlations between the maximum standardized uptake value (SUVmax) of primary tumors as reflected on preoperative FDG-PET images, the pathological features, and cancer recurrence in 124 patients with locally advanced ESCC, who were treated with NAC and esophagectomy. Results: The pre-NAC SUVmax significantly differed for the ypT status and venous invasion (VI). The post-NAC SUVmax (post-SUVmax) significantly differed for the ypT and ypN status, VI, lymphatic invasion (LI), pathological tumor response, down-staging, and recurrence. The decrease in SUVmax before and after NAC (ΔSUVmax) significantly differed for ypT status, LI, VI, pathological tumor response, down-staging, and recurrence. The survivals were significantly stratified according to the optimal cutoffs of SUVmax for predicting recurrence (post- and ΔSUVmax cutoffs: 4.2 and 30, respectively; all p<0.0001). Moreover, multivariate analysis showed that the post- and ΔSUVmax were independent predictive factors for recurrence-free survival. Conclusion: The SUVmax on preoperative FDG-PET can predict the degree of aggressiveness of the tumor in locally advanced ESCC treated with NAC.