RT Journal Article
SR Electronic
T1 Array-based Genomic Analysis of Screen-detected Gleason Score 6 and 7 Prostatic Adenocarcinomas
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 1193
OP 1200
VO 26
IS 2A
A1 RENSKE POSTMA
A1 RONALD VAN MARION
A1 MARK VAN DUIN
A1 KEES J. VISSERS
A1 JOSIANE C. WINK
A1 FRITZ H. SCHRÖDER
A1 HANS J. TANKE
A1 KAROLY SZUHAI
A1 THEO H. VAN DERKWAST
A1 HERMAN VAN DEKKEN
YR 2006
UL http://ar.iiarjournals.org/content/26/2A/1193.abstract
AB Background: Prostate cancer is known for its heterogeneous histological appearance. It is currently not clear whether this histological heterogeneity is also reflected in the genomic composition of a tumor. Materials and Methods: The cancer DNA's were retrieved from the European Randomized Study of Screening for Prostate Cancer section Rotterdam (ERSPC). Tumors with volumes 1.0-1.5 ml and a Gleason score of 3+3 or 3+4 were selected. Comparative genomic hybridization with a 3500-element BAC array was used to detect differences in the genetic content of Gleason patterns 3 and 4. Results: A total of 1155 gains and 583 losses were discriminated in 10 G3 areas; 768 gains and 497 losses were detected in 7 G4 regions. Frequent losses included chromosome arms 6q, 8p and 13q, while frequent gains were seen on 7q and 8q. There were no significant differences between Gleason patterns 3 and 4, or between Gleason grades within one cancer. Conclusion: Histological heterogeneity, defined by Gleason grades 3 and 4, does not have a genomic counterpart. Furthermore, these asymptomatic screen-detected prostate carcinomas have genetic signatures comparable with those commonly seen in symptomatic cancers. Copyright© 2006 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved