PT  - JOURNAL ARTICLE
AU  - RENSKE POSTMA
AU  - RONALD VAN MARION
AU  - MARK VAN DUIN
AU  - KEES J. VISSERS
AU  - JOSIANE C. WINK
AU  - FRITZ H. SCHRÖDER
AU  - HANS J. TANKE
AU  - KAROLY SZUHAI
AU  - THEO H. VAN DERKWAST
AU  - HERMAN VAN DEKKEN
TI  - Array-based Genomic Analysis of Screen-detected Gleason Score 6 and 7 Prostatic Adenocarcinomas
DP  - 2006 Mar 01
TA  - Anticancer Research
PG  - 1193--1200
VI  - 26
IP  - 2A
4099  - http://ar.iiarjournals.org/content/26/2A/1193.short
4100  - http://ar.iiarjournals.org/content/26/2A/1193.full
SO  - Anticancer Res2006 Mar 01; 26
AB  - Background: Prostate cancer is known for its heterogeneous histological appearance. It is currently not clear whether this histological heterogeneity is also reflected in the genomic composition of a tumor. Materials and Methods: The cancer DNA's were retrieved from the European Randomized Study of Screening for Prostate Cancer section Rotterdam (ERSPC). Tumors with volumes 1.0-1.5 ml and a Gleason score of 3+3 or 3+4 were selected. Comparative genomic hybridization with a 3500-element BAC array was used to detect differences in the genetic content of Gleason patterns 3 and 4. Results: A total of 1155 gains and 583 losses were discriminated in 10 G3 areas; 768 gains and 497 losses were detected in 7 G4 regions. Frequent losses included chromosome arms 6q, 8p and 13q, while frequent gains were seen on 7q and 8q. There were no significant differences between Gleason patterns 3 and 4, or between Gleason grades within one cancer. Conclusion: Histological heterogeneity, defined by Gleason grades 3 and 4, does not have a genomic counterpart. Furthermore, these asymptomatic screen-detected prostate carcinomas have genetic signatures comparable with those commonly seen in symptomatic cancers. Copyright© 2006 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved