RT Journal Article
SR Electronic
T1 Cancer Genetics of Sporadic Colorectal Cancer: <em>BRAF</em> and <em>PI3KCA</em> Mutations, their Impact on Signaling and Novel Targeted Therapies
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 1077
OP 1084
VO 26
IS 2A
A1 EFTYCHIA OIKONOMOU
A1 ALEXANDROS PINTZAS
YR 2006
UL http://ar.iiarjournals.org/content/26/2A/1077.abstract
AB Novel activating mutations in sporadic colorectal cancer (CRC) have recently been identified on major kinase encoding genes such as BRAF and PI3KCA. The presence of these activating point mutations, including the well characterized KRAS oncogene mutations, represent up to 75% of cases in CRC. These genes, that have been implicated in the adenoma-carcinoma transition, cause deregulation and constitutive activation of the MAP AKT/kinase pathways, rendering growth advantages to colon tumor cells. This review focuses on the key genetic alterations underlying the cumulative effect of multiple mutations within the colon cancer cell. Moreover, the currently available and alternative treatment approaches that may target these different genetic alterations are discussed, such as the novel BRAF inhibitor. Identification of novel mutations as well as differential gene expression analyzed by microarray reveal potential targets for combined therapeutic protocols which will result in personalized treatments in the near future. Copyright© 2006 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved