RT Journal Article
SR Electronic
T1 Matrix Metalloproteinase (MMP) -1, -2, -3 and -9 Promoter Polymorphisms in Colorectal Cancer
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 791
OP 795
VO 26
IS 1B
A1 ELANDER, NILS
A1 SÖDERKVIST, PETER
A1 FRANSÉN, KARIN
YR 2006
UL http://ar.iiarjournals.org/content/26/1B/791.abstract
AB Background: Matrix metalloproteinases (MMPs) are a group of matrix-degrading proteins implicated in several pathological processes, e.g., invasion and metastasis in malignant diseases such as colorectal cancer (CRC). Materials and Methods: One hundred and twenty-seven CRC patients and 208 controls were genotyped for MMP-1, -2, -3 and -9 promoter polymorphisms. The genotyping was performed with PCR/primer-extension/DHPLC or PCR/RFLP. Results: The MMP-1 2G allele was significantly associated with CRC (p=0.037). No significant association between CRC and MMP-2, -3 or -9 polymorphisms was evident. The analysis of polymorphisms in the clinicopathological subgroups displayed no significant associations. Conclusion: The MMP-1 promoter polymorphism seems to affect the susceptibility to CRC, while MMP-2, -3 and -9 polymorphisms appear less likely to have any impact on CRC. Copyright© 2006 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved