PT - JOURNAL ARTICLE AU - NILS ELANDER AU - PETER SÖDERKVIST AU - KARIN FRANSÉN TI - Matrix Metalloproteinase (MMP) -1, -2, -3 and -9 Promoter Polymorphisms in Colorectal Cancer DP - 2006 Jan 01 TA - Anticancer Research PG - 791--795 VI - 26 IP - 1B 4099 - http://ar.iiarjournals.org/content/26/1B/791.short 4100 - http://ar.iiarjournals.org/content/26/1B/791.full SO - Anticancer Res2006 Jan 01; 26 AB - Background: Matrix metalloproteinases (MMPs) are a group of matrix-degrading proteins implicated in several pathological processes, e.g., invasion and metastasis in malignant diseases such as colorectal cancer (CRC). Materials and Methods: One hundred and twenty-seven CRC patients and 208 controls were genotyped for MMP-1, -2, -3 and -9 promoter polymorphisms. The genotyping was performed with PCR/primer-extension/DHPLC or PCR/RFLP. Results: The MMP-1 2G allele was significantly associated with CRC (p=0.037). No significant association between CRC and MMP-2, -3 or -9 polymorphisms was evident. The analysis of polymorphisms in the clinicopathological subgroups displayed no significant associations. Conclusion: The MMP-1 promoter polymorphism seems to affect the susceptibility to CRC, while MMP-2, -3 and -9 polymorphisms appear less likely to have any impact on CRC. Copyright© 2006 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved