TY - JOUR T1 - The Contribution of Matrix Metalloproteinase-7 Promoter Genotypes to Hepatocellular Carcinoma Susceptibility JF - Anticancer Research JO - Anticancer Res SP - 5275 LP - 5282 DO - 10.21873/anticanres.16034 VL - 42 IS - 11 AU - TE-CHENG YUEH AU - HAO-YUAN TSAO AU - WEI-CHING CHIEN AU - CHIA-WEN TSAI AU - JEN-SHENG PEI AU - MING-HSIEN WU AU - CHOU-PIN CHEN AU - CHOU-CHEN CHEN AU - ZHI-HONG WANG AU - MEI-CHIN MONG AU - YA-CHEN YANG AU - YI-CHIH HUNG AU - DA-TIAN BAU AU - WEN-SHIN CHANG Y1 - 2022/11/01 UR - http://ar.iiarjournals.org/content/42/11/5275.abstract N2 - Background/Aim: Metalloproteinase-7 (MMP-7) has been previously found to be up-regulated in hepatocellular carcinoma (HCC) specimens and cells, favoring epithelial–mesenchymal transition. However, the contribution of MMP-7 genotypes to HCC has not been revealed to date. The study aimed to evaluate the contribution of MMP-7 promoter A-181G (rs11568818) and C-153T (rs11568819) genotypes on the risk of HCC in Taiwan, where HCC incidence is extremely high compared to worldwide data. Materials and Methods: In this case–control study, MMP-7 genotypes and their association with cigarette smoking and alcohol drinking habits were determined in 298 HCC patients and 889 healthy subjects by a typical polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) methodology. Results: Ever smokers and alcohol drinkers were represented with higher percentages in the case group compared to the control group. MMP-7 rs11568818 genotypes were not found differentially distributed in case and control groups (p for trend=0.5246). People of the analyzed cohort of the present study were all of CC genotypes at their rs11568819 polymorphic sites, without any CT or TT genotypes. As for gene–lifestyle interactions, people with variant genotypes at MMP-7 rs11568818 had the same odds for HCC development compared to the wild-type AA genotype, no matter whether the subjects belonged to the smoker, non-smoker alcohol drinker, or non-drinker groups. Conclusion: MMP-7 variant genotypes did not present any significance towards being a marker for HCC risk in Taiwanese. ER -