RT Journal Article
SR Electronic
T1 Interleukin-18 (IL-18) Cytokine Serum Concentrations Correlate With Pain Scores and the Number of Analgesic Doses Following Surgery
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 5521
OP 5526
DO 10.21873/anticanres.16057
VO 42
IS 11
A1 MAARET ESKELINEN
A1 IINA SAIMANEN
A1 TUOMAS SELANDER
A1 ANU HOLOPAINEN
A1 SAMULI ASPINEN
A1 ESA HÄMÄLÄINEN
A1 MATTI ESKELINEN
YR 2022
UL http://ar.iiarjournals.org/content/42/11/5521.abstract
AB Background/Aim: Anti- and proinflammatory cytokines and plasma high-sensitivity C-reactive protein (hs-CRP) are used to assess inflammatory stress response (ISR) following surgery. However, the serum IL-18 (interleukin-18) cytokine values versus numeric rating scale (NRS) pain score and number of analgesic doses (NAD) postoperatively are unknown. Patients and Methods: Blood levels of six interleukins (IL-18, IL-1ra, IL-6, IL-10, IL-1β, and IL-8) and hs-CRP were measured at three time points; before operation (PRE), immediately after operation (POP1), and six hours after operation (POP2) in 114 patients with cholelithiasis. Results: Following surgery, the blood levels of hs-CRP and IL-1ra, IL-6, IL-10, and IL-1β cytokines had a trend for increase (p<0.001 and p=0.014, respectively). The serum IL-18 concentrations inversely correlated to NRS and NAD during the first 24 h postoperatively. Conclusion: The correlation of IL-18 levels to NRS and NAD values supports the hypothesis that ISR and pain are related.