RT Journal Article
SR Electronic
T1 Changes in Serum Trace Element Concentrations Before and After Surgery in Resectable Breast Cancer
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 5323
OP 5334
DO 10.21873/anticanres.16039
VO 42
IS 11
A1 TAKAHASHI, ERIKO
A1 IMAI, KAZUHIRO
A1 FUKUYAMA, MAYUKO
A1 TERATA, KAORI
A1 NANJO, HIROSHI
A1 ISHIYAMA, KOICHI
A1 HIROSHIMA, YUKO
A1 YATSUYANAGI, MISAKO
A1 KUDO, CHIAKI
A1 MORISHITA, AOI
A1 WAKITA, AKIYUKI
A1 TAKASHIMA, SHINOGU
A1 SATO, YUSUKE
A1 NOMURA, KYOKO
A1 MINAMIYA, YOSHIHIRO
YR 2022
UL http://ar.iiarjournals.org/content/42/11/5323.abstract
AB Background/Aim: Minerals and trace elements (TEs) play vital roles in normal biological functions and in all cancers. Breast carcinoma is the most commonly occurring cancer in women. The aim of this study was to evaluate changes in TE levels before and after breast cancer surgery and the clinical utility and reliability of TE levels assayed using inductively coupled plasma mass spectrometry (ICP-MS). Patients and Methods: Thirteen patients with ductal carcinoma in situ (DCIS) and 34 with invasive ductal carcinoma (IDC) treated with planned surgery were enrolled between August 2017 and February 2019. Blood samples were collected before and the day after resection of the primary tumor. All enrolled patients received mastectomy or quadrantectomy and axillary lymph node dissection/biopsy. Serum TE concentrations were determined using ICP-MS. Results: Changes in boron, titanium, vanadium, chromium, copper, zinc, and selenium levels from before to after surgery differed between IDC and DCIS patients. Boron and copper levels before surgery and changes in titanium, vanadium, and chromium before and after surgery are potential predictors distinguishing DCIS from IDC. Subset analysis showed that chromium is a potential biomarker for luminal subtype, while titanium and chromium are potential biomarkers for pathological staging. Conclusion: Changes in serum TEs before and after surgery may help with diagnosis and staging of breast cancer and in establishing TE supplementation protocols.