RT Journal Article
SR Electronic
T1 Nuclear Size as Prognostic Determinant in Stage II and Stage III Colorectal Adenocarcinoma
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 455
OP 462
VO 26
IS 1B
A1 BUHMEIDA, ABDELBASET
A1 ÅLGARS, ANNIKA
A1 RISTAMÄKI, RAIJA
A1 COLLAN, YRJÖ
A1 SYRJÄNEN, KARI
A1 PYRHÖNEN, SEPPO
YR 2006
UL http://ar.iiarjournals.org/content/26/1B/455.abstract
AB Background: The prognostic value of morphometric nuclear features was assessed in stage II and stage III colorectal cancer (CRC). Materials and Methods: Primary tumors from 123 CRC patients were analyzed using an image overlay drawing system for the following nuclear size features: area, perimeter, diameter and form features. Results: The nuclear area (NA) was significantly different in tumors at different localizations (p=0.029). A large NA was a significant predictor of recurrent disease, with overall response (OR) 3.09 (1.37-6.95) (p=0.006). The NA was significantly larger in recurrent cases (106.3 μm2) than in non-recurrent ones (96.6 μm2) (p=0.007) and was a significant predictor of disease-free survival (DFS) in univariate (Kaplan-Meier) analysis (log-rank p=0.0239). However, lymph node involvement was the most powerful predictor of DFS in multivariate analysis, with OR 3.371 (95%CI 1.17-9.65) (p=0.024) and disease recurrence the only independent predictor of disease-specific survival (DSS), with OR 48.4 (95%CI 6.30-371.73). Conclusion: Quantitative measurement of the NA seems to accurately discriminate the patients, among stage II and III colorectal cancer, who are likely to develop disease recurrence. Image morphometry seems to be a useful adjunct tool in examining the subgroup of lymph node-negative patients to predict the risk of disease recurrence and indications for adjuvant therapy. Copyright© 2006 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved