<?xml version='1.0' encoding='UTF-8'?><xml><records><record><source-app name="HighWire" version="7.x">Drupal-HighWire</source-app><ref-type name="Journal Article">17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">BUHMEIDA, ABDELBASET</style></author><author><style face="normal" font="default" size="100%">ÅLGARS, ANNIKA</style></author><author><style face="normal" font="default" size="100%">RISTAMÄKI, RAIJA</style></author><author><style face="normal" font="default" size="100%">COLLAN, YRJÖ</style></author><author><style face="normal" font="default" size="100%">SYRJÄNEN, KARI</style></author><author><style face="normal" font="default" size="100%">PYRHÖNEN, SEPPO</style></author></authors><secondary-authors></secondary-authors></contributors><titles><title><style face="normal" font="default" size="100%">Nuclear Size as Prognostic Determinant in Stage II and Stage III Colorectal Adenocarcinoma</style></title><secondary-title><style face="normal" font="default" size="100%">Anticancer Research</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2006</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2006-01-01 00:00:00</style></date></pub-dates></dates><pages><style  face="normal" font="default" size="100%">455-462</style></pages><volume><style face="normal" font="default" size="100%">26</style></volume><issue><style face="normal" font="default" size="100%">1B</style></issue><abstract><style  face="normal" font="default" size="100%">Background: The prognostic value of morphometric nuclear features was assessed in stage II and stage III colorectal cancer (CRC). Materials and Methods: Primary tumors from 123 CRC patients were analyzed using an image overlay drawing system for the following nuclear size features: area, perimeter, diameter and form features. Results: The nuclear area (NA) was significantly different in tumors at different localizations (p=0.029). A large NA was a significant predictor of recurrent disease, with overall response (OR) 3.09 (1.37-6.95) (p=0.006). The NA was significantly larger in recurrent cases (106.3 μm2) than in non-recurrent ones (96.6 μm2) (p=0.007) and was a significant predictor of disease-free survival (DFS) in univariate (Kaplan-Meier) analysis (log-rank p=0.0239). However, lymph node involvement was the most powerful predictor of DFS in multivariate analysis, with OR 3.371 (95%CI 1.17-9.65) (p=0.024) and disease recurrence the only independent predictor of disease-specific survival (DSS), with OR 48.4 (95%CI 6.30-371.73). Conclusion: Quantitative measurement of the NA seems to accurately discriminate the patients, among stage II and III colorectal cancer, who are likely to develop disease recurrence. Image morphometry seems to be a useful adjunct tool in examining the subgroup of lymph node-negative patients to predict the risk of disease recurrence and indications for adjuvant therapy. Copyright© 2006 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved</style></abstract></record></records></xml>