RT Journal Article
SR Electronic
T1 Minichromosome Maintenance Proteins MCM-3, MCM-5, MCM-7, and Ki-67 as Proliferative Markers in Adrenocortical Tumors
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 1151
OP 1159
DO 10.21873/anticanres.13224
VO 39
IS 3
A1 APOROWICZ, MICHAL
A1 CZOPNIK, PIOTR
A1 KUBICKA, ELIZA
A1 PIOTROWSKA, ALEKSANDRA
A1 DZIEGIEL, PIOTR
A1 BOLANOWSKI, MAREK
A1 DOMOSLAWSKI, PAWEL
YR 2019
UL http://ar.iiarjournals.org/content/39/3/1151.abstract
AB Background/Aim: Morphological features, combined with Ki-67 proliferative index, remain the standard for discriminating benign and malignant adrenocortical tumors. The aim of this study was to evaluate the role of minichromosome maintenance proteins MCM-3, MCM-5, MCM-7, and Ki-67 as proliferative markers in adrenocortical tumors. Materials and Methods: Specimens of 81 adrenocortical adenomas and 3 adrenocortical carcinomas were stained with antibodies against MCM-3, 5, 7 and Ki-67. Results: Malignant tumors were characterized by a greater size (p=0.017), volume (p=0.017), and higher levels of Ki-67 (p=0.005), MCM-3 (p=0.005), MCM-7 (p=0.008), but not MCM-5 (p=0.069). The markers' levels were independent from the tumors' size and volume, the patient's age and hormonal status. ROC curves showed Ki-67 (AUC 0.984), MCM-3 (AUC 0.984), and MCM-7 (AUC 0.950), but not MCM-5 (AUC 0.820) to be reliable markers. Conclusion: Ki-67, MCM-3, and MCM-7, but not MCM-5 are reliable proliferative and diagnostic markers in discerning benign and malignant adrenocortical tumors.