<?xml version='1.0' encoding='UTF-8'?><xml><records><record><source-app name="HighWire" version="7.x">Drupal-HighWire</source-app><ref-type name="Journal Article">17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">HIRANO, AKIRA</style></author><author><style face="normal" font="default" size="100%">SHIMIZU, TADAO</style></author><author><style face="normal" font="default" size="100%">IMAMURA, HIROSHI</style></author><author><style face="normal" font="default" size="100%">WATANABE, OSAMU</style></author><author><style face="normal" font="default" size="100%">KINOSHITA, JUN</style></author><author><style face="normal" font="default" size="100%">OKABE, TOSHIHIRO</style></author><author><style face="normal" font="default" size="100%">KIMURA, KIYOMI</style></author><author><style face="normal" font="default" size="100%">KAMIMURA, MARI</style></author><author><style face="normal" font="default" size="100%">DOMOTO, KAORU</style></author><author><style face="normal" font="default" size="100%">AIBA, MOTOHIKO</style></author><author><style face="normal" font="default" size="100%">OGAWA, KENJI</style></author></authors><secondary-authors></secondary-authors></contributors><titles><title><style face="normal" font="default" size="100%">The Combination of Epirubicin plus Docetaxel as Neoadjuvant Chemotherapy in Locally-advanced Breast Cancer</style></title><secondary-title><style face="normal" font="default" size="100%">Anticancer Research</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2006</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2006-01-01 00:00:00</style></date></pub-dates></dates><pages><style  face="normal" font="default" size="100%">581-584</style></pages><volume><style face="normal" font="default" size="100%">26</style></volume><issue><style face="normal" font="default" size="100%">1B</style></issue><abstract><style  face="normal" font="default" size="100%">Background: The purpose of this study was to evaluate the activity and toxicity of epirubicin plus docetaxel as neoadjuvant chemotherapy for locally advanced breast cancer. Patients and Methods: In this single-center, phase II trial, twenty-one patients with locally advanced breast cancer (T&gt;3 cm or N&gt;1) received epirubicin (70 mg/m2) and docetaxel (60 mg/m2) on Day 1 of each cycle for up to 6 cycles. Results: Clinically complete responses (CR) were observed in 5 patients and partial responses were observed in 14 patients. The clinical response rate was 90.5% (95% confidence interval, 78.0-99.9). Eleven patients (52.4%) underwent breast conserving surgery. Pathological response evaluation revealed 2 CR (9.5%). Grade 4 neutropenia was recorded in 81.0% of the patients and febrile neutropenia occurred in 1 patient. Conclusion: The combination of epirubicin plus docetaxel was an active and well-tolerated treatment for locally-advanced breast cancer. Copyright© 2006 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved</style></abstract></record></records></xml>