<?xml version='1.0' encoding='UTF-8'?><xml><records><record><source-app name="HighWire" version="7.x">Drupal-HighWire</source-app><ref-type name="Journal Article">17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">WANG, LI-SHU</style></author><author><style face="normal" font="default" size="100%">HUANG, YI-WEN</style></author><author><style face="normal" font="default" size="100%">SUGIMOTO, YASURO</style></author><author><style face="normal" font="default" size="100%">LIU, SULING</style></author><author><style face="normal" font="default" size="100%">CHANG, HSIANG-LIN</style></author><author><style face="normal" font="default" size="100%">YE, WEIPING</style></author><author><style face="normal" font="default" size="100%">SHU, SHERRY</style></author><author><style face="normal" font="default" size="100%">LIN, YOUNG C.</style></author></authors><secondary-authors></secondary-authors></contributors><titles><title><style face="normal" font="default" size="100%">Conjugated Linoleic Acid (CLA) Up-regulates the Estrogen-regulated Cancer Suppressor Gene, Protein Tyrosine Phosphatase γ (PTPγ), in Human Breast Cells</style></title><secondary-title><style face="normal" font="default" size="100%">Anticancer Research</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2006</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2006-01-01 00:00:00</style></date></pub-dates></dates><pages><style  face="normal" font="default" size="100%">27-34</style></pages><volume><style face="normal" font="default" size="100%">26</style></volume><issue><style face="normal" font="default" size="100%">1A</style></issue><abstract><style  face="normal" font="default" size="100%">Background: Conjugated linoleic acid (CLA), a naturally occurring compound found in ruminants products, has been shown to possess anticancer properties in vivo and in vitro. There are several CLA isomers in ruminant-produced foods, among which t10,c12-CLA and c9,t11-CLA are the most potent. Protein tyrosine phosphatase γ (PTPγ) has been implicated as a tumor suppressor gene in kidney and lung cancers. Our previous results indicated that estradiol-17β (E2)-induced suppression of PTPγ may play a role in mammary tumorigenesis. Materials and Methods: The effects of t10,c12-CLA and c9,t11-CLA on PTPγ mRNA expression in human breast epithelial cells and stromal cells, isolated from surgical specimens of mammoplasty and breast cancer patients, were detected and quantified by RT-PCR. Results: The PTPγ mRNA expression was lower in cancer than in normal breast cells. Both t10,c12-CLA and c9,t11-CLA significantly (p&lt;0.05) increased the PTPγ mRNA levels in primary cultured normal breast epithelial cells, normal breast stromal cells and breast cancer epithelial cells, but not in breast cancer stromal cells. t10,c12-CLA appeared to be the most active isomer in estrogen receptor α(ERα)-positive human breast cancer epithelial cells. Conclusion: The results indicate that dietary CLA might serve as a chemo-preventive and chemo-therapeutic agent in human breast cancers by up-regulating the estrogen-regulated tumor suppressor gene, PTPγ expression. Copyright© 2006 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved</style></abstract></record></records></xml>