RT Journal Article
SR Electronic
T1 Clinical Outcomes of Scanning Carbon-ion Radiotherapy for Soft Tissue Sarcoma of the Extremities
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 3701
OP 3706
DO 10.21873/anticanres.15859
VO 42
IS 7
A1 YOSUKE TAKAKUSAGI
A1 ITSUKO SERIZAWA
A1 HIROAKI KOGE
A1 KIO KANO
A1 SATOSHI SHIMA
A1 KEISUKE TSUCHIDA
A1 NOBUTAKA MIZOGUCHI
A1 DAISAKU YOSHIDA
A1 HIROYUKI KATOH
A1 TORU HIRUMA
A1 TADASHI KAMADA
YR 2022
UL http://ar.iiarjournals.org/content/42/7/3701.abstract
AB Background/Aim: Carbon-ion radiotherapy (CIRT) has been reported to obtain favorable results in the treatment of bone and soft tissue malignancies; however, studies on CIRT for soft tissue sarcomas (STS) of the extremities are limited. Here, we have retrospectively evaluated the therapeutic efficacy and adverse events associated with scanning CIRT (sCIRT) for STS of the extremities at our institution. Patients and Methods: Thirteen consecutive patients with STS who underwent sCIRT between January 2017 and January 2020 were included in the study. The total dose of sCIRT was set at 67.2-70.4 Gy (RBE), which was provided in 16 fractions. Overall survival (OS), progression-free survival (PFS), and local control (LC) were estimated using the Kaplan–Meier method. Toxicity was evaluated using Common Terminology Criteria for Adverse Events v5.0. Results: The cohort consisted of 10 males and 3 females with a median age of 69 years (range=38-95 years). Median duration of observation was 31.8 months (range=7.4-56.4 months). Tumors were localized to the upper extremity in 2 cases and to the lower extremity in 11 cases. Median maximum tumor diameter was 11.7 cm (range=3.0-36.6 cm), while 3-year OS, PFS, and LC were 61.5%, 44.9%, and 79.1%, respectively. Acute toxicity of grade 3 or higher was not observed. Late toxicity included grade 3 peripheral nerve palsy and decreased range of motion in 1 and 1 patient each. Late toxicity of Grade 4 or higher was not observed. Conclusion: sCIRT for STS of the extremities demonstrates favorable therapeutic results with acceptable toxicity.