TY - JOUR T1 - Significant Contribution of Interleukin-18 Genotypes to Lung Cancer Risk in Taiwanese JF - Anticancer Research JO - Anticancer Res SP - 3381 LP - 3387 DO - 10.21873/anticanres.15825 VL - 42 IS - 7 AU - MENG-FENG WU AU - LI-HSIOU CHEN AU - NING-YI HSIA AU - YI-CHENG SHEN AU - TE-CHUN SHEN AU - ZHI-HONG WANG AU - YA-CHEN YANG AU - YUN-CHI WANG AU - WEN-SHIN CHANG AU - TE-CHUN HSIA AU - DA-TIAN BAU AU - CHIA-WEN TSAI Y1 - 2022/07/01 UR - http://ar.iiarjournals.org/content/42/7/3381.abstract N2 - Background/Aim: The elevated expression of interleukin-18 (IL-18) among lung cancer patients raised our curiosity to examine the role of IL-18 genotypes in lung cancer. Materials and Methods: IL-18 -656 (rs1946519), -607 (rs1946518), and -137 (rs187238) genotypes of 358 lung cancer cases and 716 controls were determined via the PCR-RFLP methodology. Results: The distributions of genotypic and allelic frequencies of IL-18 -607, but not those of -656 or -137, were differentially distributed between cases and controls. IL-18 -607 AC and CC genotypes were both lower (45.8% and 16.2%) in lung cancer patients compared to controls (51.4% and 24.7%). In addition, IL-18 -607 AC and CC genotypes were of significantly lower percentages both among non-smokers and smokers. Otherwise, no differential distribution was found regarding IL-18 -656 or -137. Conclusion: IL-18 -607 C allele can serve as a protective predictor for lung cancer risk in Taiwanese. ER -