PT  - JOURNAL ARTICLE
AU  - MENG-FENG WU
AU  - LI-HSIOU CHEN
AU  - NING-YI HSIA
AU  - YI-CHENG SHEN
AU  - TE-CHUN SHEN
AU  - ZHI-HONG WANG
AU  - YA-CHEN YANG
AU  - YUN-CHI WANG
AU  - WEN-SHIN CHANG
AU  - TE-CHUN HSIA
AU  - DA-TIAN BAU
AU  - CHIA-WEN TSAI
TI  - Significant Contribution of Interleukin-18 Genotypes to Lung Cancer Risk in Taiwanese
AID  - 10.21873/anticanres.15825
DP  - 2022 Jul 01
TA  - Anticancer Research
PG  - 3381--3387
VI  - 42
IP  - 7
4099  - http://ar.iiarjournals.org/content/42/7/3381.short
4100  - http://ar.iiarjournals.org/content/42/7/3381.full
SO  - Anticancer Res2022 Jul 01; 42
AB  - Background/Aim: The elevated expression of interleukin-18 (IL-18) among lung cancer patients raised our curiosity to examine the role of IL-18 genotypes in lung cancer. Materials and Methods: IL-18 -656 (rs1946519), -607 (rs1946518), and -137 (rs187238) genotypes of 358 lung cancer cases and 716 controls were determined via the PCR-RFLP methodology. Results: The distributions of genotypic and allelic frequencies of IL-18 -607, but not those of -656 or -137, were differentially distributed between cases and controls. IL-18 -607 AC and CC genotypes were both lower (45.8% and 16.2%) in lung cancer patients compared to controls (51.4% and 24.7%). In addition, IL-18 -607 AC and CC genotypes were of significantly lower percentages both among non-smokers and smokers. Otherwise, no differential distribution was found regarding IL-18 -656 or -137. Conclusion: IL-18 -607 C allele can serve as a protective predictor for lung cancer risk in Taiwanese.