TY - JOUR T1 - Impact of Dose-Volume Parameters of Parotid Glands on Xerostomia in Patients Irradiated for Head-and-Neck Cancer JF - Anticancer Research JO - Anticancer Res SP - 3551 LP - 3556 DO - 10.21873/anticanres.15841 VL - 42 IS - 7 AU - DIRK RADES AU - BRITTA WARWAS AU - FLORIAN CREMERS AU - KARSTEN GERULL AU - CHRISTIAN IDEL AU - KARL L. BRUCHHAGE AU - SAMER G. HAKIM AU - STEVEN E. SCHILD Y1 - 2022/07/01 UR - http://ar.iiarjournals.org/content/42/7/3551.abstract N2 - Background/Aim: Optimal planning of radiotherapy for head-and-neck cancers should consider the risk of xerostomia. This study investigated the prognostic value of dosevolume parameters of the parotid glands. Patients and Methods: Dose-volume parameters were evaluated for xerostomia in 145 patients including D40 (minimum dose to 40% of corresponding parotid volume), D60 (minimum dose to 60%), D80 (minimum dose to 80%), and mean dose of ipsilateral, contralateral, and bilateral parotid glands. Results: Grade ≥2 xerostomia was significantly associated with D40 of ipsilateral and all parameters of bilateral glands; trends were found for all other parameters. Grade ≥3 xerostomia was significantly associated with D80 of bilateral glands; trends were found for other parameters of ipsilateral and bilateral glands. Conclusion: Since grade ≥2 xerostomia was associated with all parameters, D40, D60, and D80 did not provide additional information to mean doses. D80 of bilateral glands is a new factor and more predictive than mean dose regarding grade ≥3 xerostomia. ER -