TY - JOUR T1 - Prevention of Surgery-induced Suppression of Granulocyte Function by Intravenous Application of a Fermented Extract from <em>Viscum album</em> L. in Breast Cancer Patients JF - Anticancer Research JO - Anticancer Res SP - 4753 LP - 4757 VL - 25 IS - 6C AU - ARNDT BÜSSING AU - MECHTILD BISCHOF AU - WOLFGANG HATZMANN AU - FELIX BARTSCH AU - DANYL SOTO-VERA AU - EVA-MARIA FRONK AU - MARTIN GMEINDL AU - GERBURG M. STEIN Y1 - 2005/11/01 UR - http://ar.iiarjournals.org/content/25/6C/4753.abstract N2 - Surgical stress and anaesthetics are able to suppress the immune system. This may accelerate the growth and metastasis of residual cancer cells. As Viscum album L. extracts (VA-E) are known to exert both effects, immunomodulating and apoptosis-inducing properties, a Good-Clinical-Practice-guided, prospective bi-centric phase II study was conducted to measure the influence of a perioperative intravenous application of a VA-E on granulocyte function. In 98 patients with breast cancer, it was shown that a single intravenous application of the standardized VA-E “Iscador® M special” in a final concentration of 1 mg/individual prior to surgery prevented the surgery-associated inhibition of the oxidative burst. As no VA-E-related side-effects were observed, this distinct route of application may be a rationale to restrict immunosuppression by surgical stress and anaesthesia. Copyright© 2005 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved ER -