PT  - JOURNAL ARTICLE
AU  - HUNG, GUANG-UEI
AU  - TSAI, CHIEN-CHUNG
AU  - TSAI, SHIH-CHUAN
AU  - LIN, WAN-YU
TI  - Comparison of Tc-99m Sestamibi and F-18 FDG-PET in the Assessment of Multiple Myeloma
DP  - 2005 Nov 01
TA  - Anticancer Research
PG  - 4737--4741
VI  - 25
IP  - 6C
4099  - http://ar.iiarjournals.org/content/25/6C/4737.short
4100  - http://ar.iiarjournals.org/content/25/6C/4737.full
SO  - Anticancer Res2005 Nov 01; 25
AB  - Background: Tc-99m methoxy-isobutyl-isonitrile (MIBI) has been reported to be a useful tracer in patients with multiple myeloma (MM). Few articles have reported the potential value of fluorine-18 fluorodeoxyglucose positron emission tomography (FDG-PET) in the evaluation of MM. Therefore, the purpose of this study was to compare the diagnostic abilities of the MIBI scan and the FDG-PET scan in the evaluation of MM. Materials and Methods: Twelve patients with MM were included. All patients received a radiological skeletal survey, MIBI scan and FDG-PET scan. Results: Thirty-four lesions (19 soft tissue lesions and 15 skeletal lesions) plus 5 cases of bone marrow involvement were detected. The conventional skeletal X-ray survey detected 4 soft tissue lesions (21.1%), 12 skeletal lesions (80%), but no bone marrow involvement (0%). The MIBI scan found 4 cases of bone marrow involvement (80%), 13 soft tissue lesions (68.4%) and 12 skeletal lesions (80%). The PET scan detected 5 cases of bone marrow involvement (100%), 17 soft tissue lesions (89.5%) and 14 skeletal lesions (93.3%). Conclusion: Both the MIBI and the FDG-PET scans are useful in the evaluation of patients with MM. However, FDG-PET can detect more lesions than the MIBI scan in patients with MM. Copyright© 2005 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved