RT Journal Article
SR Electronic
T1 The Prognostic Relevance of Preoperative CEA and CA19-9 for Ampulla of Vater Carcinoma
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 3169
OP 3176
DO 10.21873/anticanres.15806
VO 42
IS 6
A1 SATOSHI MATSUI
A1 YUSUKE YAMAMOTO
A1 YUKIYASU OKAMURA
A1 TAKAAKI ITO
A1 RYO ASHIDA
A1 KATSUHISA OHGI
A1 MIHOKO YAMADA
A1 SHIMPEI OTSUKA
A1 KATSUHIKO UESAKA
A1 TEIICHI SUGIURA
YR 2022
UL http://ar.iiarjournals.org/content/42/6/3169.abstract
AB Background/Aim: Increased serum levels of carcinoembryonic antigen (CEA) and carbohydrate antigen 199 (CA19-9) are established prognostic factors in ampulla of Vater carcinoma (AC). We determined the best cut-off values of preoperative CEA and CA19-9 and compared the prognostic power of preoperative CEA with that of preoperative CA19-9 for overall survival (OS). Patients and Methods: A total of 116 consecutive patients without jaundice who underwent macroscopic curative resection for AC between January 2002 and August 2019 were enrolled. Results: Using the minimum p-value approach based on the OS, the optimal CEA cut-off value was found to be 6.5 ng/ml; however, the cut-off value of CA19-9 could not be determined, as no significant p value was identified. The OS of the patients with CEA >6.5 ng/ml (n=5; 3-year OS, 20.0%) was significantly worse than that with CEA ≤6.5 ng/ml (n=111; 3-year OS, 76.6%; p<0.001). A Cox proportional hazards analysis for OS revealed CEA >6.5 ng/ml (hazard ratio=4.01, p=0.019) to be an independent prognostic factor. Conclusion: In patients with AC, although the CA19-9 optimal cut-off value could not be determined, CEA >6.5 ng/ml independently affected long-term survival after resection.