PT  - JOURNAL ARTICLE
AU  - MASATOSHI NAKAMURA
AU  - HITOSHI ISHIKAWA
AU  - KAYOKO OHNISHI
AU  - KEIICHIRO BABA
AU  - TAKASHI SAITO
AU  - TAISUKE SUMIYA
AU  - MOTOHIRO MURAKAMI
AU  - YUICHI HIROSHIMA
AU  - KEI NAKAI
AU  - MASASHI MIZUMOTO
AU  - TOSHIYUKI OKUMURA
AU  - HIDEYUKI SAKURAI
TI  - Proton Beam Therapy in Elderly Patients With cT1-3N0M0 Non-small Cell Lung Cancer
AID  - 10.21873/anticanres.15778
DP  - 2022 Jun 01
TA  - Anticancer Research
PG  - 2953--2960
VI  - 42
IP  - 6
4099  - http://ar.iiarjournals.org/content/42/6/2953.short
4100  - http://ar.iiarjournals.org/content/42/6/2953.full
SO  - Anticancer Res2022 Jun 01; 42
AB  - Background/Aim: To investigate the outcomes of elderly patients with cT1-3N0M0 non-small cell lung cancer (NSCLC) undergoing proton beam therapy (PBT). Patients and Methods: Between 2009 and 2019, 110 patients receiving hypofractionated PBT for cT1-3N0M0 NSCLC were retrospectively reviewed. Results: The median follow-up was 36.5 months (range=4.9-131.0 months). In the elderly group (80 years or older), the 3-year overall survival and progression-free survival rates were 79.8% and 73.9%, respectively, and the corresponding rates in the younger group were 80.5% and 61.2%, respectively. Grade 3 radiation pneumonitis (RP) was observed in 4.4% patients in the young group, whereas no grade 3 RP was observed in the elderly group. Age was not a risk factor for symptomatic RP. There were no significant differences in the survival and adverse events between the elderly and younger groups. Conclusion: PBT may be a reasonable approach for treating lung cancer in elderly patients with T1-3N0M0 NSCLC.