PT  - JOURNAL ARTICLE
AU  - HIDEYA ONISHI
AU  - NAOYA IWAMOTO
AU  - KEITA SAKANASHI
AU  - SATOKO KOGA
AU  - YASUHIRO OYAMA
AU  - KOSUKE YANAI
AU  - KATSUYA NAKAMURA
AU  - SHUNTARO NAGAI
AU  - AKIKO FUJIMURA
AU  - KAZUNORI NAKAYAMA
AU  - KEIGO OZONO
AU  - AKIO YAMASAKI
TI  - PTPN3 Could Βe a Therapeutic Target of Pancreatic Cancer
AID  - 10.21873/anticanres.15768
DP  - 2022 Jun 01
TA  - Anticancer Research
PG  - 2869--2874
VI  - 42
IP  - 6
4099  - http://ar.iiarjournals.org/content/42/6/2869.short
4100  - http://ar.iiarjournals.org/content/42/6/2869.full
SO  - Anticancer Res2022 Jun 01; 42
AB  - Background/Aim: Recently, protein tyrosine phosphatase non-receptor type 3 (PTPN3) has gained attention. However, the role of PTPN3 in cancer has not been fully elucidated. In the present study, we analyzed the role of PTPN3 in pancreatic cancer and investigated whether PTPN3 could be a new therapeutic target for pancreatic cancer. Materials and Methods: Two pancreatic ductal adenocarcinoma (PDAC) cell lines were used as target cells. Cell proliferation was investigated using cell counting and a xenograft mouse model. Migration and invasion were analyzed using Transwell inserts. Activation-related signaling molecules were examined by western blotting. Results: PTPN3 contributes to the proliferation, migration, and invasion of PDAC cells in vitro. PTPN3 promotes tumor growth in a mouse xenograft model, an action mediated partially through the MAPK pathway. Conclusion: PTPN3 could be a new therapeutic target for pancreatic cancer.