RT Journal Article
SR Electronic
T1 Reduced α- and β-catenin Expression Predicts Shortened Survival in Local Prostate Cancer
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 4707
OP 4712
VO 25
IS 6C
A1 AALTOMAA, S.
A1 KÄRJÄ, V.
A1 LIPPONEN, P.
A1 ISOTALO, T.
A1 KANKKUNEN, J.-P.
A1 TALJA, M.
A1 MOKKA, R.
YR 2005
UL http://ar.iiarjournals.org/content/25/6C/4707.abstract
AB The aim of this study was to determine the prognostic value of α- and, β-catenin expressions in local prostate cancer (PC). Materials and Methods: One hundred and eighty-one PC patients treated with radical prostatectomy were followed-up for a mean of 7.3 years. The α- and, β-catenin expression were analysed by immunohistochemistry TMT (tissue microarray technique) and light microscopy. Results: Strong α-catenin expression was related to low Gleason grade (p<0.001), cancer-free seminal vesicles (p=0.04) and low preoperative PSA (p=0.02). Strong, β-catenin expression was related to low Gleason grade (p<0.001) and cancer-free seminal vesicle status (p=0.03). Absence of nuclear, β-catenin expression was related to local disease (pT1-T2) (p=0.05). α-catenin (p=0.06), β-catenin (p=0.05), Gleason grade (p=0.03) and capsular invasion (p=0.01) were related to PSA recurrence in patients who reached PSA zero postoperatively. PSA recurrence-free survival (RFS) was significantly related to Gleason grade (p<0.001), capsule invasion (p=0.01), perineural growth (p=0.05) and preoperative PSA (p=0.05). In Cox's analysis, independent predictors of PSA RFS were Gleason grade (p<0.001) and capsular invasion (p=0.006). Low expressions of α- (p=0.06) and, β-catenin (p=0.05) were related to shortened PSA RFS. Survival was related to low α- (p=0.011) and, β-catenin (p=0.016) expressions. Independent predictors of shortened survival were seminal vesicle invasion (p=0.016) and low α-catenin expression (p=0.049). Conclusion: Reduced α- or, β-catenin expressions are related to malignant phenotype in local prostate cancer and predict PSA failure as well as shortened survival. Copyright© 2005 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved