RT Journal Article
SR Electronic
T1 Large Tumor Size and High Neutrophil-to-lymphocyte Ratio Predicts Poor Prognosis After Pneumonectomy or Sleeve Lobectomy in Patients With Non-small-cell Lung Cancer
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 3029
OP 3034
DO 10.21873/anticanres.15788
VO 42
IS 6
A1 TAKUMA TSUKIOKA
A1 NOBUHIRO IZUMI
A1 HIROAKI KOMATSU
A1 HIDETOSHI INOUE
A1 RYUICHI ITO
A1 SATOSHI SUZUKI
A1 NORITOSHI NISHIYAMA
YR 2022
UL http://ar.iiarjournals.org/content/42/6/3029.abstract
AB Background/Aim: The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are useful biomarkers in non-small cell lung cancer (NSCLC). The aim of this study was to identify novel prognostic factors after pneumonectomy or sleeve lobectomy. Patients and Methods: The clinical courses of 68 patients with NSCLC who underwent pneumonectomy or sleeve lobectomy were retrospectively investigated. Results: High NLR (p=0.002) and PLR (p=0.006), and large tumor (>40 mm) (p=0.024) were indicative of poor prognosis in univariate analysis. High NLR (p=0.021) and large tumor (>40 mm) (p=0.017) remained independent factors indicating poor prognosis in multivariate analysis. Eighteen patients with both high NLR and large tumor (>40 mm) had significantly poorer prognoses than the remaining patients, 10 of them having recurrences within a short time after surgery. Conclusion: A high NLR and large tumor size indicate a poor prognosis after pneumonectomy or sleeve lobectomy. Our findings may be helpful in selecting optimal treatments for this subgroup of patients.