TY - JOUR T1 - Large Tumor Size and High Neutrophil-to-lymphocyte Ratio Predicts Poor Prognosis After Pneumonectomy or Sleeve Lobectomy in Patients With Non-small-cell Lung Cancer JF - Anticancer Research JO - Anticancer Res SP - 3029 LP - 3034 DO - 10.21873/anticanres.15788 VL - 42 IS - 6 AU - TAKUMA TSUKIOKA AU - NOBUHIRO IZUMI AU - HIROAKI KOMATSU AU - HIDETOSHI INOUE AU - RYUICHI ITO AU - SATOSHI SUZUKI AU - NORITOSHI NISHIYAMA Y1 - 2022/06/01 UR - http://ar.iiarjournals.org/content/42/6/3029.abstract N2 - Background/Aim: The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are useful biomarkers in non-small cell lung cancer (NSCLC). The aim of this study was to identify novel prognostic factors after pneumonectomy or sleeve lobectomy. Patients and Methods: The clinical courses of 68 patients with NSCLC who underwent pneumonectomy or sleeve lobectomy were retrospectively investigated. Results: High NLR (p=0.002) and PLR (p=0.006), and large tumor (>40 mm) (p=0.024) were indicative of poor prognosis in univariate analysis. High NLR (p=0.021) and large tumor (>40 mm) (p=0.017) remained independent factors indicating poor prognosis in multivariate analysis. Eighteen patients with both high NLR and large tumor (>40 mm) had significantly poorer prognoses than the remaining patients, 10 of them having recurrences within a short time after surgery. Conclusion: A high NLR and large tumor size indicate a poor prognosis after pneumonectomy or sleeve lobectomy. Our findings may be helpful in selecting optimal treatments for this subgroup of patients. ER -