RT Journal Article
SR Electronic
T1 Combined Overexpression of EGFR and Estrogen Receptor α Correlates with a Poor Outcome in Lung Cancer
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 4693
OP 4698
VO 25
IS 6C
A1 HIDEKI KAWAI
A1 AKIRA ISHII
A1 KIYOTADA WASHIYA
A1 TOSHIKO KONNO
A1 HIROTO KON
A1 CHIHARU YAMAYA
A1 IWAO ONO
A1 JUNICHI OGAWA
YR 2005
UL http://ar.iiarjournals.org/content/25/6C/4693.abstract
AB Background: The aim of the present study was to determine the prognostic significance of the combined overexpression of epidermal growth factor receptor (EGFR) and estrogen receptor α (ER-α) in non-small cell lung cancer (NSCLC). Patients and Methods: An immunohistochemical assessment of EGFR and ER-α expression was carried out in tumor specimens from 122 consecutive NSCLC patients after surgery. Results: Of the 122 tumors examined, 57 (46.7%) overexpressed EGFR, 63 (51.6%) overexpressed ER-α, while 33 (27%) overexpressed both EGFR and ER-α. Univariate analyses showed that the overexpression of EGFR or ER-α correlated with the histological grade (p=0.01 and p=0.03, respectively) and a poorer prognosis (p=0.007), while overexpression of ER-α also correlated with smoking (p=0.02). Multivariate analysis showed the combined overexpression of EGFR and ER-α to be an independent indicator of poorer prognosis (p=0.0006). Conclusion: The combined overexpression of EGFR and ER-α in NCLSC patients is predictive of poor outcome and, thus, represents a valuable prognostic factor. Copyright© 2005 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved