RT Journal Article
SR Electronic
T1 Gc Protein (Vitamin D-binding Protein): Gc Genotyping and GcMAF Precursor Activity
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 3689
OP 3695
VO 25
IS 6A
A1 HIDEKO NAGASAWA
A1 YOSHIHIRO UTO
A1 HIDEYUKI SASAKI
A1 NATSUKO OKAMURA
A1 AYA MURAKAMI
A1 SHINICHI KUBO
A1 KENNETH L. KIRK
A1 HITOSHI HORI
YR 2005
UL http://ar.iiarjournals.org/content/25/6A/3689.abstract
AB The Gc protein (human group-specific component (Gc), a vitamin D-binding protein or Gc globulin), has important physiological functions that include involvement in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5α for neutrophils in inflammation and macrophage activation (mediated by a GalNAc-modified Gc protein (GcMAF)). In this review, the structure and function of the Gc protein is focused on especially with regard to Gc genotyping and GcMAF precursor activity. A discussion of the research strategy “GcMAF as a target for drug discovery” is included, based on our own research. Copyright© 2005 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved