PT  - JOURNAL ARTICLE
AU  - HIDEKO NAGASAWA
AU  - YOSHIHIRO UTO
AU  - HIDEYUKI SASAKI
AU  - NATSUKO OKAMURA
AU  - AYA MURAKAMI
AU  - SHINICHI KUBO
AU  - KENNETH L. KIRK
AU  - HITOSHI HORI
TI  - Gc Protein (Vitamin D-binding Protein): Gc Genotyping and GcMAF Precursor Activity
DP  - 2005 Nov 01
TA  - Anticancer Research
PG  - 3689--3695
VI  - 25
IP  - 6A
4099  - http://ar.iiarjournals.org/content/25/6A/3689.short
4100  - http://ar.iiarjournals.org/content/25/6A/3689.full
SO  - Anticancer Res2005 Nov 01; 25
AB  - The Gc protein (human group-specific component (Gc), a vitamin D-binding protein or Gc globulin), has important physiological functions that include involvement in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5α for neutrophils in inflammation and macrophage activation (mediated by a GalNAc-modified Gc protein (GcMAF)). In this review, the structure and function of the Gc protein is focused on especially with regard to Gc genotyping and GcMAF precursor activity. A discussion of the research strategy “GcMAF as a target for drug discovery” is included, based on our own research. Copyright© 2005 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved