TY - JOUR T1 - Bevacizumab as Treatment for Chemotherapy-resistant Pancreatic Cancer JF - Anticancer Research JO - Anticancer Res SP - 3637 LP - 3639 VL - 25 IS - 5 AU - HOWARD W. BRUCKNER AU - VICTOR R. HREHOROVICH AU - HARINDER S. SAWHNEY Y1 - 2005/09/01 UR - http://ar.iiarjournals.org/content/25/5/3637.abstract N2 - A 74-year-old male, with refractory stage IV pancreatic cancer, was successfully treated with bevacizumab 5 mg/kg and combination chemotherapy consisting of gemcitabine, fluorouracil, leucovorin, irinotecan and cisplatin (GFLIP) every two weeks. The patient had rapidly failed initial treatment with GFLIP given in an identical dose and schedule. Large new liver lesions developed during active treatment. On adding bevacizumab to GFLIP, serial measures on CT confirmed an objective (RECIST) response. The tumor marker CA19-9 fell rapidly from 24,000 U/ml to less than 400 U/ml. This was accomplished with clinically inconsequential side-effects. This is the first demonstrated benefit of bevacizumab used in combination with previously failed chemotherapy for pancreatic cancer. Copyright© 2005 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved ER -