RT Journal Article
SR Electronic
T1 Combination of Serum Albumin and Cholinesterase Levels as Prognostic Indicator in Patients ith Colorectal Cancer
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 1085
OP 1090
DO 10.21873/anticanres.13217
VO 39
IS 2
A1 MANABU YAMAMOTO
A1 HIROAKI SAITO
A1 CHIHIRO UEJIMA
A1 AKIMITSU TANIO
A1 YOICHIRO TADA
A1 TOMOYUKI MATSUNAGA
A1 TERUHISA SAKAMOTO
A1 SOICHIRO HONJO
A1 KEIGO ASHIDA
A1 YOSHIYUKI FUJIWARA
YR 2019
UL http://ar.iiarjournals.org/content/39/2/1085.abstract
AB Background/Aim: Nutritional status is strongly associated with cancer prognosis. The aim of this study was to identify the most useful combination of nutrition-related serum markers for predicting prognosis of patients with colorectal cancer (CRC). Patients and Methods: A total of 523 patients who underwent proctocolectomies for CRC at our hospital were enrolled in this study. Serum concentrations of albumin, cholinesterase and total cholesterol, and total peripheral lymphocyte count (TLC) were used as nutrition-related markers. Results: In multivariate analysis of nutrition-related markers, serum albumin and cholinesterase levels were found to be independent prognostic indicators. Cut-off values from receiver operating characteristic analyses were used to sort patients as ChEHigh or ChELow (serum cholinesterase level ≥ or <221.5), and as AlbHigh or AlbLow (serum albumin level ≥ or <3.85). We then sorted them into three groups: ChEHigh/AlbHigh (Group A); ChEHigh/AlbLow or ChELow/AlbHigh (Group B); and ChELow/AlbLow (Group C). Their 5-year overall survival rates differed significantly (Group A: 81.6%, Group B: 62.1%, Group C: 42.7%, p<0.0001); as did their 5-year disease-specific survival rates (Group A: 90.1%, Group B: 73.8%, Group C: 62.2%, p<0.0001). Conclusion: The combination of serum cholinesterase and albumin levels is useful for predicting the prognosis of patients with CRC.