PT - JOURNAL ARTICLE AU - MANABU YAMAMOTO AU - HIROAKI SAITO AU - CHIHIRO UEJIMA AU - AKIMITSU TANIO AU - YOICHIRO TADA AU - TOMOYUKI MATSUNAGA AU - TERUHISA SAKAMOTO AU - SOICHIRO HONJO AU - KEIGO ASHIDA AU - YOSHIYUKI FUJIWARA TI - Combination of Serum Albumin and Cholinesterase Levels as Prognostic Indicator in Patients ith Colorectal Cancer AID - 10.21873/anticanres.13217 DP - 2019 Feb 01 TA - Anticancer Research PG - 1085--1090 VI - 39 IP - 2 4099 - http://ar.iiarjournals.org/content/39/2/1085.short 4100 - http://ar.iiarjournals.org/content/39/2/1085.full SO - Anticancer Res2019 Feb 01; 39 AB - Background/Aim: Nutritional status is strongly associated with cancer prognosis. The aim of this study was to identify the most useful combination of nutrition-related serum markers for predicting prognosis of patients with colorectal cancer (CRC). Patients and Methods: A total of 523 patients who underwent proctocolectomies for CRC at our hospital were enrolled in this study. Serum concentrations of albumin, cholinesterase and total cholesterol, and total peripheral lymphocyte count (TLC) were used as nutrition-related markers. Results: In multivariate analysis of nutrition-related markers, serum albumin and cholinesterase levels were found to be independent prognostic indicators. Cut-off values from receiver operating characteristic analyses were used to sort patients as ChEHigh or ChELow (serum cholinesterase level ≥ or <221.5), and as AlbHigh or AlbLow (serum albumin level ≥ or <3.85). We then sorted them into three groups: ChEHigh/AlbHigh (Group A); ChEHigh/AlbLow or ChELow/AlbHigh (Group B); and ChELow/AlbLow (Group C). Their 5-year overall survival rates differed significantly (Group A: 81.6%, Group B: 62.1%, Group C: 42.7%, p<0.0001); as did their 5-year disease-specific survival rates (Group A: 90.1%, Group B: 73.8%, Group C: 62.2%, p<0.0001). Conclusion: The combination of serum cholinesterase and albumin levels is useful for predicting the prognosis of patients with CRC.