RT Journal Article
SR Electronic
T1 Pathological Significance and Prognostic Role of WWC1 in Upper Urinary Tract Urothelial Cancer
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 2311
OP 2317
DO 10.21873/anticanres.15710
VO 42
IS 5
A1 KURATA, HIROKI
A1 MITSUNARI, KENSUKE
A1 KONDO, TSUBASA
A1 MASATO, MASAHITO
A1 ITO, HIDENORI
A1 MUKAE, YUTA
A1 NAKAMURA, YUICHIRO
A1 MATSUO, TOMOHIRO
A1 OHBA, KOJIRO
A1 MOCHIZUKI, YASUSHI
A1 SAKAI, HIDEKI
A1 MIYATA, YASUYOSHI
YR 2022
UL http://ar.iiarjournals.org/content/42/5/2311.abstract
AB Background/Aim: WW and C2 domain-containing 1 (WWC1) protein is a suppressor of malignancies. However, there is no information on the pathological significance of WWC1 in upper urinary tract cancer (UTUC). Patients and Methods: In this study, WWC1 immunoreactivity was investigated in 152 non-metastatic UTUC samples. The relationships between WWC1 expression and grade, pT stage, proliferative index (using an antibody to Ki-67), and the immunohistochemical expression of matrix metalloproteinase (MMP)-2 and -9 were evaluated. Results: WWC1 expression was negatively associated with tumor grade and pT stage (p<0.001). Positive expression of WWC1 was a better predictor of the UTUC recurrence and subsequent metastasis, and the multivariate analysis showed that WWC1 expression was a significant predictor of subsequent metastasis (hazard ratio=0.29, p=0.020). WWC1 expression inversely correlated with the proliferative index (odds ratio=2.59, p=0.023) and expression of MMP9 (odds ratio=2.19, p=0.040) but not with MMP2 expression, by multivariate analyses. Conclusion: WWC1 expression was negatively associated with malignant aggressiveness via the suppression of cancer cell proliferation and MMP9 expression in patients with UTUC. This suggests WWC1 to be a useful predictor and novel therapeutic target in patients with UTUC.