RT Journal Article SR Electronic T1 Dynamic Integrated Backscatter Detects Radiotherapy-induced Cardiac Changes Better than Strain Analysis – A Prospective Three-year Study JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 2507 OP 2517 DO 10.21873/anticanres.15729 VO 42 IS 5 A1 SUVI SIRKKU TUOHINEN A1 TANJA SKYTTA A1 HEINI HUHTALA A1 VESA VIRTANEN A1 PIRKKO-LIISA KELLOKUMPU-LEHTINEN A1 PEKKA RAATIKAINEN YR 2022 UL http://ar.iiarjournals.org/content/42/5/2507.abstract AB Background/Aim: Radiotherapy (RT) related myocardial changes were analyzed by deformation imaging echocardiography in this study. Patients and Methods: Ninety-nine breast cancer patients were studied at baseline, after chemotherapy, after RT, and three years after RT (3Y). Eighty patients received RT only, and twenty patients had right-sided breast cancer. Echocardiography included cyclic variation of the integrated backscatter in the septum (sCV) and posterior wall (pCV), global longitudinal strain (GLS), and left ventricular ejection fraction (LVEF). Results: In patients with left-sided breast cancer, sCV declined from 11.3±3.3 dB at baseline to 10.3±2.9 dB after RT (p=0.001). No changes were observed after chemotherapy (p=0.211) or in patients with right-sided breast cancer after RT (p=0.977). No other parameters declined after RT. The decline in sCV was independently associated with the left anterior descending coronary artery radiation dose (β=–0.290, p=0.020). Conclusion: In contrast to other parameters, sCV correlated with heart radiation dose.