PT  - JOURNAL ARTICLE
AU  - SUVI SIRKKU TUOHINEN
AU  - TANJA SKYTTA
AU  - HEINI HUHTALA
AU  - VESA VIRTANEN
AU  - PIRKKO-LIISA KELLOKUMPU-LEHTINEN
AU  - PEKKA RAATIKAINEN
TI  - Dynamic Integrated Backscatter Detects Radiotherapy-induced Cardiac Changes Better than Strain Analysis – A Prospective Three-year Study
AID  - 10.21873/anticanres.15729
DP  - 2022 May 01
TA  - Anticancer Research
PG  - 2507--2517
VI  - 42
IP  - 5
4099  - http://ar.iiarjournals.org/content/42/5/2507.short
4100  - http://ar.iiarjournals.org/content/42/5/2507.full
SO  - Anticancer Res2022 May 01; 42
AB  - Background/Aim: Radiotherapy (RT) related myocardial changes were analyzed by deformation imaging echocardiography in this study. Patients and Methods: Ninety-nine breast cancer patients were studied at baseline, after chemotherapy, after RT, and three years after RT (3Y). Eighty patients received RT only, and twenty patients had right-sided breast cancer. Echocardiography included cyclic variation of the integrated backscatter in the septum (sCV) and posterior wall (pCV), global longitudinal strain (GLS), and left ventricular ejection fraction (LVEF). Results: In patients with left-sided breast cancer, sCV declined from 11.3±3.3 dB at baseline to 10.3±2.9 dB after RT (p=0.001). No changes were observed after chemotherapy (p=0.211) or in patients with right-sided breast cancer after RT (p=0.977). No other parameters declined after RT. The decline in sCV was independently associated with the left anterior descending coronary artery radiation dose (β=–0.290, p=0.020). Conclusion: In contrast to other parameters, sCV correlated with heart radiation dose.