PT - JOURNAL ARTICLE AU - MING-HSIEN WU AU - CHAO-HSUAN CHEN AU - CHOU-PIN CHEN AU - TAI-LIN HUANG AU - TE-CHENG YUEH AU - ZHI-HONG WANG AU - CHIA-WEN TSAI AU - JEN-SHENG PEI AU - MEI-CHIN MONG AU - YA-CHEN YANG AU - DA-TIAN BAU AU - WEN-SHIN CHANG TI - Contribution of <em>5-Methyltetrahydrofolate-Homocysteine Methyltransferase Reductase</em> Genotypes to Colorectal Cancer in Taiwan AID - 10.21873/anticanres.15716 DP - 2022 May 01 TA - Anticancer Research PG - 2375--2382 VI - 42 IP - 5 4099 - http://ar.iiarjournals.org/content/42/5/2375.short 4100 - http://ar.iiarjournals.org/content/42/5/2375.full SO - Anticancer Res2022 May 01; 42 AB - Background/Aim: 5-methyltetrahydrofolate-homocysteine methyltransferase reductase (MTRR) is responsible for folate metabolism, and we aimed to investigate its genetic role in colorectal cancer (CRC) among Taiwanese. Materials and Methods: A total of 362 cases and 362 controls were recruited and their MTRR rs1801394 (A66G) and rs1532268 (C524T) genotypes were examined. The behavioral factors and clinicalpathological factors were also analyzed. Results: MTRR rs1801394 genotypes were associated with CRC risk (p for trend=0.0087). In detail, G/G genotype was associated with lower risk (p=0.0049, OR=0.39, 95%CI=0.20-0.76). As for allelic frequency analysis, G allele was also associated with decreased CRC risk (p=0.0026, OR=0.68, 95%CI=0.53-0.88). There was no significant association as for MTRR rs1532268. Among non-smokers and non-alcohol drinkers, those with G/G genotype were at 0.38- and 0.46-fold odds of having CRC. There were no significant protective effects among smokers or alcohol drinkers. Conclusion: MTRR rs1801394 GG genotype can be a protective marker for CRC risk in Taiwan.