RT Journal Article
SR Electronic
T1 Expression of LncRNAs in HPV-induced Carcinogenesis and Cancer Cachexia: A Study in K14-HPV16 Mice
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 2443
OP 2460
DO 10.21873/anticanres.15723
VO 42
IS 5
A1 TÂNIA R. DIAS
A1 JOANA M. O. SANTOS
A1 DIOGO ESTÊVÃO
A1 NATÁLIA R. COSTA
A1 VERÓNICA F. MESTRE
A1 BEATRIZ MEDEIROS-FONSECA
A1 MARGARIDA M.S.M. BASTOS
A1 PAULA A. OLIVEIRA
A1 RUI M. GIL DA COSTA
A1 RUI MEDEIROS
YR 2022
UL http://ar.iiarjournals.org/content/42/5/2443.abstract
AB Aim: To evaluate the expression of lincRNA-p21, H19, EMX2OS, SNHG12 and MALAT1 in a mouse model of human papillomavirus 16 (HPV16)-induced carcinogenesis and cachexia. Materials and Methods: Chest skin, ear, tongue, penis and gastrocnemius muscle samples from wild-type mice (HPV−) and K14-HPV16 male mice (HPV+) were collected to evaluate the expression of the selected lncRNAs using real-time PCR (qPCR). Results: In chest skin and ear, H19, SNHG12, EMX2OS and lincRNA-p21 were down-regulated in HPV+ versus HPV– mice. In tongue and penile tissues, there was only down-regulation of lincRNA-p21 in HPV+ mice. Additionally, in penile tissue, lincRNA-p21 expression decreased in HPV-induced lesions comparing with normal tissues. In gastrocnemius muscle, MALAT1 was up-regulated and lincRNA-p21 was down-regulated in HPV+ versus HPV–mice. Conclusion: H19, SNHG12, EMX2OS and lincRNA-p21 may be involved in HPV-induced carcinogenesis. In addition, MALAT1 and lincRNA-p21 may play a role in muscle wasting and contribute to cancer cachexia.