TY - JOUR T1 - Impact of Infectious Complications on Survival and Recurrence of Patients With Stage II/III Colorectal Cancer: A Multicenter Retrospective Study JF - Anticancer Research JO - Anticancer Res SP - 2763 LP - 2769 DO - 10.21873/anticanres.15755 VL - 42 IS - 5 AU - HIROSHI TAMAGAWA AU - TORU AOYAMA AU - MASAKATSU NUMATA AU - KEISUKE KAZAMA AU - YOSUKE ATSUMI AU - KENTA IGUCHI AU - MIHWA JU AU - SHO SAWAZAKI AU - SUMITO SATO AU - KAZUKI KANO AU - TAKASHI OHSHIMA AU - TAKANOBU YAMADA AU - TENI GODAI AU - AKIO HIGUCHI AU - HIROYUKI SAEKI AU - NORIO YUKAWA AU - YASUSHI RINO Y1 - 2022/05/01 UR - http://ar.iiarjournals.org/content/42/5/2763.abstract N2 - Background/Aim: Postoperative complications are associated with increased recurrence in colorectal cancer (CRC). We investigated the impact of infectious complications on the recurrence of CRC and overall survival after curative surgery in a single study group. Patients and Methods: In total, 1,668 patients who underwent radical resection for CRC in Yokohama City University, Yokohama Minami Kyosai Hospital, and Kanagawa Cancer Center between 2011 and 2019 were reviewed. Patients were classified into those with infectious complications (IC group) and those without infectious complications (Non-IC group). The risk factors for recurrence-free survival (RFS) and overall survival (OS) were analyzed. Results: Postoperative complications were found in 560 of the 1,668 patients (33.5%), and IC, which occurred in 312 patients (18.7%), included pneumonia, anastomotic leakage, and intraperitoneal abscess. The 5-year OS rates in the Non-IC and IC groups were 95.5% and 90.4%, respectively, while the 5-year RFS rates were 74.4% and 68.1%, respectively. The multivariate analysis demonstrated that postoperative IC were significant independent risk factors for OS and RFS. Conclusion: The presence of postoperative IC after CRC resection is associated with decreased long-term survival. The surgical procedure, surgical strategy, and perioperative care should be carefully planned in order to avoid causing IC. ER -