PT  - JOURNAL ARTICLE
AU  - BARBARA BACHTIARY
AU  - IRENE HERBACEK
AU  - THOMAS ZIDECK
AU  - THOMAS-HENDRIK KNOCKE
AU  - JOHANNES DIMOPOULOS
AU  - RICHARD POETTER
AU  - MICHAEL MICKSCHE
TI  - Impact of Radiotherapy with and without Concurrent Cisplatin on Lymphocyte Subpopulations in Cervical Cancer Patients
DP  - 2005 Nov 01
TA  - Anticancer Research
PG  - 4673--4678
VI  - 25
IP  - 6C
4099  - http://ar.iiarjournals.org/content/25/6C/4673.short
4100  - http://ar.iiarjournals.org/content/25/6C/4673.full
SO  - Anticancer Res2005 Nov 01; 25
AB  - Background: The impact of radiotherapy alone (RT-alone) and radiotherapy plus concurrent chemotherapy with cisplatin (RT-CHT) was determined for lymphocyte subpopulations in cervical cancer patients. Materials and Methods: Thirty-four women were treated either with RT-alone (n=14) or RT-CHT (n=20). Peripheral lymphocytes were collected before, immediately after and 6, 12 and 24 weeks after completion of treatment. Flow cytometric analysis included total T-cells, T-helper-cells, T-suppressor-cells, T-cytotoxic-cells, NK-cells, B-cells and the CD4+/CD8+ratio. Results: Twenty-four weeks after treatment, B-cells had recovered to pretreatment levels whereas total lymphocyte counts, T-helper and T-cytotoxic-cells were still significantly reduced in both groups. In contrast, T-suppressor-cells and NK-cells had recovered to pretreatment levels only in patients who received RT-alone and were still significantly reduced in patients who received RT-CHT. Conclusion: RT-alone and RT-CHT induce a significant and prolonged suppression of all lymphocyte subpopulations. RT-CHT, but not RT-alone, causes a prolonged suppression of NK-cells and T-suppressor cells. Copyright© 2005 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved