TY - JOUR T1 - Expression of Caveolin-1 in Pleomorphic Carcinoma of the Lung is Correlated with a Poor Prognosis JF - Anticancer Research JO - Anticancer Res SP - 4631 LP - 4637 VL - 25 IS - 6C AU - KYUNG CHUL MOON AU - GEON KOOK LEE AU - SEONG-HO YOO AU - YOON KYUNG JEON AU - JIN-HAENG CHUNG AU - JUNGHO HAN AU - DOO HYUN CHUNG Y1 - 2005/11/01 UR - http://ar.iiarjournals.org/content/25/6C/4631.abstract N2 - Background: Caveolin-1 is implicated in the oncogenic transformation of cells as a tumor suppressor. In several human carcinomas, the expression of caveolin-1 has been reported to be correlated with prognosis. The present study was designed to clarify the clinicopathological significance of caveolin-1 expression in pleomorphic carcinoma of the lung (PCL). Patients and Methods: Twenty-one cases of PCL were immunohistochemically evaluated for caveolin-1 expression. Results: Caveolin-1 was expressed in 18 out of 21 cases. Patients with high caveolin-1 expression in PCL showed lower disease-free and overall survival rates than those with low caveolin-1 expression. However, the expression level of caveolin-1 in PCL was not significantly correlated with age, stage, pT category, pN category, or tumor size. Conclusion: These results suggest that the overexpression of caveolin-1 is significantly correlated with a poor prognosis in patients with PCL and that it is a marker for predicting prognosis in PCL. Copyright© 2005 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved ER -