RT Journal Article
SR Electronic
T1 Expression of Caveolin-1 in Pleomorphic Carcinoma of the Lung is Correlated with a Poor Prognosis
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 4631
OP 4637
VO 25
IS 6C
A1 KYUNG CHUL MOON
A1 GEON KOOK LEE
A1 SEONG-HO YOO
A1 YOON KYUNG JEON
A1 JIN-HAENG CHUNG
A1 JUNGHO HAN
A1 DOO HYUN CHUNG
YR 2005
UL http://ar.iiarjournals.org/content/25/6C/4631.abstract
AB Background: Caveolin-1 is implicated in the oncogenic transformation of cells as a tumor suppressor. In several human carcinomas, the expression of caveolin-1 has been reported to be correlated with prognosis. The present study was designed to clarify the clinicopathological significance of caveolin-1 expression in pleomorphic carcinoma of the lung (PCL). Patients and Methods: Twenty-one cases of PCL were immunohistochemically evaluated for caveolin-1 expression. Results: Caveolin-1 was expressed in 18 out of 21 cases. Patients with high caveolin-1 expression in PCL showed lower disease-free and overall survival rates than those with low caveolin-1 expression. However, the expression level of caveolin-1 in PCL was not significantly correlated with age, stage, pT category, pN category, or tumor size. Conclusion: These results suggest that the overexpression of caveolin-1 is significantly correlated with a poor prognosis in patients with PCL and that it is a marker for predicting prognosis in PCL. Copyright© 2005 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved