PT  - JOURNAL ARTICLE
AU  - MOON, KYUNG CHUL
AU  - LEE, GEON KOOK
AU  - YOO, SEONG-HO
AU  - JEON, YOON KYUNG
AU  - CHUNG, JIN-HAENG
AU  - HAN, JUNGHO
AU  - CHUNG, DOO HYUN
TI  - Expression of Caveolin-1 in Pleomorphic Carcinoma of the Lung is Correlated with a Poor Prognosis
DP  - 2005 Nov 01
TA  - Anticancer Research
PG  - 4631--4637
VI  - 25
IP  - 6C
4099  - http://ar.iiarjournals.org/content/25/6C/4631.short
4100  - http://ar.iiarjournals.org/content/25/6C/4631.full
SO  - Anticancer Res2005 Nov 01; 25
AB  - Background: Caveolin-1 is implicated in the oncogenic transformation of cells as a tumor suppressor. In several human carcinomas, the expression of caveolin-1 has been reported to be correlated with prognosis. The present study was designed to clarify the clinicopathological significance of caveolin-1 expression in pleomorphic carcinoma of the lung (PCL). Patients and Methods: Twenty-one cases of PCL were immunohistochemically evaluated for caveolin-1 expression. Results: Caveolin-1 was expressed in 18 out of 21 cases. Patients with high caveolin-1 expression in PCL showed lower disease-free and overall survival rates than those with low caveolin-1 expression. However, the expression level of caveolin-1 in PCL was not significantly correlated with age, stage, pT category, pN category, or tumor size. Conclusion: These results suggest that the overexpression of caveolin-1 is significantly correlated with a poor prognosis in patients with PCL and that it is a marker for predicting prognosis in PCL. Copyright© 2005 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved