<?xml version='1.0' encoding='UTF-8'?><xml><records><record><source-app name="HighWire" version="7.x">Drupal-HighWire</source-app><ref-type name="Journal Article">17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">MOON, KYUNG CHUL</style></author><author><style face="normal" font="default" size="100%">LEE, GEON KOOK</style></author><author><style face="normal" font="default" size="100%">YOO, SEONG-HO</style></author><author><style face="normal" font="default" size="100%">JEON, YOON KYUNG</style></author><author><style face="normal" font="default" size="100%">CHUNG, JIN-HAENG</style></author><author><style face="normal" font="default" size="100%">HAN, JUNGHO</style></author><author><style face="normal" font="default" size="100%">CHUNG, DOO HYUN</style></author></authors><secondary-authors></secondary-authors></contributors><titles><title><style face="normal" font="default" size="100%">Expression of Caveolin-1 in Pleomorphic Carcinoma of the Lung is Correlated with a Poor Prognosis</style></title><secondary-title><style face="normal" font="default" size="100%">Anticancer Research</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2005</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2005-11-01 00:00:00</style></date></pub-dates></dates><pages><style  face="normal" font="default" size="100%">4631-4637</style></pages><volume><style face="normal" font="default" size="100%">25</style></volume><issue><style face="normal" font="default" size="100%">6C</style></issue><abstract><style  face="normal" font="default" size="100%">Background: Caveolin-1 is implicated in the oncogenic transformation of cells as a tumor suppressor. In several human carcinomas, the expression of caveolin-1 has been reported to be correlated with prognosis. The present study was designed to clarify the clinicopathological significance of caveolin-1 expression in pleomorphic carcinoma of the lung (PCL). Patients and Methods: Twenty-one cases of PCL were immunohistochemically evaluated for caveolin-1 expression. Results: Caveolin-1 was expressed in 18 out of 21 cases. Patients with high caveolin-1 expression in PCL showed lower disease-free and overall survival rates than those with low caveolin-1 expression. However, the expression level of caveolin-1 in PCL was not significantly correlated with age, stage, pT category, pN category, or tumor size. Conclusion: These results suggest that the overexpression of caveolin-1 is significantly correlated with a poor prognosis in patients with PCL and that it is a marker for predicting prognosis in PCL. Copyright© 2005 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved</style></abstract></record></records></xml>