RT Journal Article
SR Electronic
T1 Des-γ-carboxy Prothrombin (PIVKA-II)-producing Mediastinal Embryonal Carcinoma with Features of Hepatoid Differentiation
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 4569
OP 4571
VO 25
IS 6C
A1 HASEGAWA, YASUYUKI
A1 TOMITA, KATSUYUKI
A1 HASHIMOTO, KIYOSHI
A1 SHIGEOKA, YASUSHI
A1 WATANABE, MASANARI
A1 YAMASAKI, AKIRA
A1 SHIMIZU, EIJI
YR 2005
UL http://ar.iiarjournals.org/content/25/6C/4569.abstract
AB The case of a 48-year-old man with primary nonseminomatous embryonal carcinoma at the posterior mediastinum is described. The patient displayed extremely high plasma levels of Des-γ-carboxy prothrombin (PIVKA-II) (4040 mAU/ml). Ultrasonography and dynamic computed tomography ruled out hepatocellular carcinoma (HCC) or liver metastasis. After preoperative systemic chemotherapy, total tumor resection was performed. Postoperatively, the plasma levels of PIVKA-II returned to within the normal range (24 mAU/ml). An immnohistochemical study using anti-PIVKA-II monoclonal antibody revealed the cytoplasmic expression of PIVKA-II in the carcinoma cells. These results indicate that tumor cells, which are manifested as hepatoid differentiation, may produce PIVKA-II. This case seems to be the first case reported in which PIVKA-II was produced by nonseminomatous mediastinal embryonal carcinoma without HCC or liver metastasis. Copyright© 2005 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved