RT Journal Article
SR Electronic
T1 Expression of BRCA1, HER-1 (EGFR) and HER-2 in Sporadic Breast Cancer and Relationships to Other Clinicopathological Prognostic Features
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 4535
OP 4541
VO 25
IS 6C
A1 ANSQUER, YAN
A1 MANDELBROT, LAURENT
A1 LEHY, THÉRESE
A1 SALOMON, LAURENCE
A1 DHAINAUT, CAROLINE
A1 MADELENAT, PATRICK
A1 FELDMANN, GÉRARD
A1 WALKER, FRANCINE
YR 2005
UL http://ar.iiarjournals.org/content/25/6C/4535.abstract
AB Background: The BRCA1 caretaker gene is associated with poor prognostic features in hereditary breast cancer and may also play a role in sporadic breast cancer (SBC). HER-1 and HER-2 overexpression is associated with adverse prognosis in SBC. We studied whether BRCA1 expression was associated with HER1, HER2 and other prognostic features in SBC. Patients and Methods: Fifty newly-diagnosed SBC patients were studied for prognostic features and immunohistochemical expressions of BRCA1, HER-1 and HER-2. Results: Tumors were positive for BRCA1 in 26%, HER-1 in 32% and HER-2 in 20% of cases. Lack of BRCA1 expression was associated with node metastases and decreased estrogen receptor. HER-2 expression was associated with young age, HER-1, Ki67 and decreased hormone receptors. No correlation was observed between BRCA1 and HER-1 or HER-2. Conclusion: In SBC, the lack of BRCA1 expression was associated with poor prognostic features, but unrelated to HER-1 and HER-2. HER2 and HER-1 were, however, highly correlated. Copyright© 2005 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved