PT  - JOURNAL ARTICLE
AU  - ANSQUER, YAN
AU  - MANDELBROT, LAURENT
AU  - LEHY, THÉRESE
AU  - SALOMON, LAURENCE
AU  - DHAINAUT, CAROLINE
AU  - MADELENAT, PATRICK
AU  - FELDMANN, GÉRARD
AU  - WALKER, FRANCINE
TI  - Expression of BRCA1, HER-1 (EGFR) and HER-2 in Sporadic Breast Cancer and Relationships to Other Clinicopathological Prognostic Features
DP  - 2005 Nov 01
TA  - Anticancer Research
PG  - 4535--4541
VI  - 25
IP  - 6C
4099  - http://ar.iiarjournals.org/content/25/6C/4535.short
4100  - http://ar.iiarjournals.org/content/25/6C/4535.full
SO  - Anticancer Res2005 Nov 01; 25
AB  - Background: The BRCA1 caretaker gene is associated with poor prognostic features in hereditary breast cancer and may also play a role in sporadic breast cancer (SBC). HER-1 and HER-2 overexpression is associated with adverse prognosis in SBC. We studied whether BRCA1 expression was associated with HER1, HER2 and other prognostic features in SBC. Patients and Methods: Fifty newly-diagnosed SBC patients were studied for prognostic features and immunohistochemical expressions of BRCA1, HER-1 and HER-2. Results: Tumors were positive for BRCA1 in 26%, HER-1 in 32% and HER-2 in 20% of cases. Lack of BRCA1 expression was associated with node metastases and decreased estrogen receptor. HER-2 expression was associated with young age, HER-1, Ki67 and decreased hormone receptors. No correlation was observed between BRCA1 and HER-1 or HER-2. Conclusion: In SBC, the lack of BRCA1 expression was associated with poor prognostic features, but unrelated to HER-1 and HER-2. HER2 and HER-1 were, however, highly correlated. Copyright© 2005 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved